Day 2 :
- Nanobiotechnology
Session Introduction
Luis Jesus Villarreal-Gómez
University of Sonora, México
Title: Mucoadhesive electrospun fibers in oral drug delivery
Biography:
Dr. Luis Jesús Villarreal-Gómez, studied Chemistry-Biology at the University of Sonora, Hermosillo, México and graduated in 2004. He then received his Ph.D. degree in 2013 at the University Autonomous of Baja California, Tijuana, México where he joined as a full research professor. Dr. Villarreal is founder and editor in chief of the Revista de Ciencias Tecnológicas (RECIT) (ISSN 2594-1925) and is editorial board member of several journals edited from MDPI, Hindawi, BenthamOpen, amongst others. Until now, he has published 35 papers and has reviewed more than 139 reviews. His research lines are biomaterials, tissue engineering, drug delivery systems, and biotechnology.
Abstract:
The necessity of new systems for drug delivery in children due to the difficulty of the correct dose administration when the drug carrier is not easy to administrate. Mucoadhesive electrospun fibrous systems are an interesting alternative for the treatment of pathologies in the oral cavity due to their capacity to release pharmaceutical drugs at a fast and sustained rate. Electrospun fibers have many characteristics that make them ideal drug carriers for local delivery. Mucoadhesives fibrous systems of poly (vinyl alcohol) (PVA) and poly (vinyl pyrrolidone) (PVP) loaded with propranolol and dexamethasone phosphate will be discussed for their potential application in the oral cavity. Physicochemical (SEM, FTIR, TGA, DSC) and biological (MTT assay) characterization will be described in order to present the morphology, chemical composition, and thermal behavior of the fibrous mats, and cytotoxicity in fibroblast will be visualized, drug delivery rate, mucoadhesive and degradation rate will be also discussed. The evaluated mucoadhesive loaded fibers presented potential characteristics to be used in the oral cavity, where successfully tridimensional fibrous scaffolds were fabricated with an average fiber diameter of about 368 ± 161 nm, thermal stability higher than 250oC, fibers were degraded completely before 15 min and high mucoadhesive and biocompatibility in fibroblast were observed. PVP loaded fibers with dexamethasone phosphate are proposed for endodontic procedures avoiding injection of the anti-inflammatory drug and PVA loaded fibers with propranolol for the treatment of hemangiomas in children.
Biography:
Salah Abdel-Gawad Aly is a highly esteemed professor specializing in reinforced concrete structures, with a wealth of experience and expertise in his field. He has made significant contributions to the advancement of construction and engineering practices throughout his career. Currently serving as a professor at the Housing & Building National Research Center (HPNRC) in Cairo, Egypt, Salah Abdel-Gawad Aly has dedicated his life to teaching, research, and the development of innovative solutions for the construction industry.
Abstract:
A judicious use of resources, by using by-products and waste materials, and a lower environmental impact, by reducing carbon dioxide emission and virgin aggregate extraction, allow approaching sustainable building development. Recycled aggregate concrete (RAC) containing supplementary cementitious material (SCM), if satisfactory concrete properties are achieved, can be an example of such sustainable construction materials. Fine recycled aggregates are seen as the last choice in recycling for concrete production. Many references quote their detrimental influence on the most important characteristics of concrete; compressive and tensile strength; modulus of elasticity; water absorption; shrinkage; carbonation and chloride penetration. These two last characteristics are fundamental in terms of the long-term durability or reinforced concrete. This paper deals with the short-term deflection of reinforced super Crete beams made of sea-sand as recycled fine aggregate (RFA). Experimental work was carried out to investigate the effects of tension & compression reinforcement ratios and span- to-depth ratio on the short-term deflection. Based on the experimental results of the tested specimens, the present study shows that the sea-sand as recycled fine aggregate (RFA) can be successfully used as a construction material for flexural members subjected to different types of loading provided that adding an organic polymer to the mixing water to limit the Cl- and SO3 content and to control the pH value up to the specified limit according to the Egyptian code. The test results showed also that the maximum deflection of the test specimens decreases with the increase of the reinforcement ratio. On the other hand, the deflection increases with the increase in span-to-depth ratio. This paper presents the main results of this research, drawing some conclusions on the feasibility of using this type of aggregate in structural concrete, while taking into account any ensuing obvious positive environmental impact.